1982;17:51721. A.D.A.M. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. All rights reserved. Milk thistle grows in Europe but can also be found in the United States and South America. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Liquid forms of this product may contain sugar and/or alcohol. In clinical trials, milk thistle appears to be well tolerated in recommended doses. This mixture contains chemical compounds, some of which may have benefits for human health. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Consult your doctor before using this product. Milk thistle is sold as an oral capsule, tablet and liquid extract. It is unknown if this product passes into breast milk. Milk thistle. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. We avoid using tertiary references. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . Dupuis ML, Conti F, Maselli A, et al. 2007;2007(4):CD003620. Milk thistle (PDQ) health professional version. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. This herb is native to Southern Europe and is used widely for its benefits. Use milk thistle as directed to prevent an overdose. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Milk thistle is available as a supplement from many health food stores. How this happens is yet to be studied. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. However, there is no solid evidence that supports these claims. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. Consult your doctor or pharmacist for more details. It is a member of the asteraceae family, which also includes sunflowers and daisies. Milk Thistle. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Natural Medicines website. Hepatology. Can you drink alcohol while taking milk thistle? Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Keep supplements in areas out of the reach of pets and children. Other potential benefits include . If you notice other effects not listed above, contact your doctor or pharmacist. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Hence, limit its usage if you experience any adverse reactions. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. 2016;5147468. doi:10.1155/2016/5147468. A very serious allergic reaction to this product is rare. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Is the ketogenic diet right for autoimmune conditions? Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Regardless, interactions are still possible. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Current studies on milk thistle use a wide range of doses. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. This article will explore the potential uses of milk thistle. Medical research on milk thistle and liver health has led to mixed results. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. These side effects may be mild or severe. Olive Oil Vs. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. However, few of these claims are supported by solid evidence. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. However, preliminary research suggests it may be worth trying alongside conventional treatments. Take this product by mouth as directed. Check out our. Toxicity is also possible if too much milk thistle is taken. There are other supplements that work similarly to milk thistle. Certain individuals might experience weakness with milk thistle. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). ), SAGE Journals. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Milk thistle comes in many forms, including tea. JAMA. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Oxidative stress is a potential cause of Alzheimers disease. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. No supplement is intended to treat, cure, or prevent disease. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Certain reports also state that milk thistle can cause skin rashes and hives (3). The terms "milk thistle" and "silymarin" are often used interchangeably. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Agency for Healthcare Research and Quality (US); 2000. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Save the high-quality PDF version on your device now. Silymarin is believed to have antioxidant properties. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Avoid combinations; the risk of the interaction outweighs the benefit. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. You can buy milk thistle online in the supplement form. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Check with your physician if you have any of the. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. de Avelar CR, Pereira EM, de Farias Costa PR, et al. We explore the potential health benefits of milk thistle below. Medical News Today only shows you brands and products that we stand behind. An important part of taking supplements is proper storage. World J Gastroenterol. It is possible to take too much milk thistle. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. While side effects are not necessarily common when taking milk thistle, they are possible. Milk thistle. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Product may contain sugar and/or alcohol and hives ( 3 ) a Systematic and! Available evidence suggests that milk thistle Interactions there are 4 drugs known to with... Cells in a laboratory environment which also includes sunflowers and daisies and thistle... Is a herb loaded with antioxidants and is used widely for its anti-inflammatory properties PR et! With antioxidants and is not intended for medical advice, diagnosis or treatment commonly sold in capsule form but also... 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